Sestino is a border land and, like all areas that are located at the crossroads of different cultures, is nowadays the result of the history, traditions and customs of the peoples who have passed through here over the centuries.
Sestino is called "the Roman city," as if it were par excellence, because of the many legacies it preserves from that era; however, an even more ancient past is certain, evidenced by findings belonging to the Etruscans, Picentes and Umbrians. It is true, however, that in the first century B.C. the Romans built a real city here, with monumental buildings.