Located at the foot of the last stretch of the Tuscan Apennines, Sansepolcro dominates the Vatiberina. It opens into a vast mountain and hilly amphitheater bordered by Alpe della Luna, Massa Trabaria, the hills of neighboring Umbria, the Aretino and the 'Alpe di Catenaia. The Sansepolcro area is surrounded by rolling green hills with expanses of tobacco.
Tradition attributes a religious origin to Sansepolcro. According to the story, two pilgrim saints, Arcano and Egidio were returning from the Holy Land and stopped in this valley to erect a chapel to house the Holy Relics.
Over the years, the cathedral dedicated to San Giovanni was built on this chapel and subsequently the whole village emerged, for this reason it's called "del Santo Sepolcro" (Of the Holy Sepulcher).